Bisquick Chicken Enchilada Bake is an easy, family-friendly casserole made with rotisserie chicken, taco seasoning, enchilada sauce and mozzarella cheese!
Bisquick Chicken Enchilada Bake: Your New Favorite Easy Weeknight Casserole
In the quest for delicious, fuss-free meals that everyone at the dinner table will love, the Bisquick Chicken Enchilada Bake stands out as a true culinary hero. This casserole isn’t just a dish; it’s a celebration of comfort food that combines the zesty flavors of Mexican cuisine with the comforting ease of a classic American casserole. Perfect for busy weeknights or casual gatherings, this recipe transforms simple ingredients into an extraordinary meal that’s both satisfying and incredibly flavorful.
What makes this enchilada bake truly special is its clever use of shortcuts without compromising on taste. By leveraging pantry staples and readily available ingredients like tender rotisserie chicken, aromatic taco seasoning, and a rich green chile enchilada sauce, you can whip up a hearty meal with minimal effort. The result is a bubbly, cheesy, and deeply savory casserole that will undoubtedly become a staple in your recipe rotation.
Experience Unbeatable Flavor with Minimal Effort: The Ultimate Bisquick Chicken Enchilada Bake
While some casseroles might not win awards for their aesthetic appeal, the Bisquick Chicken Enchilada Bake proves that taste is truly what matters most. With just a handful of straightforward ingredients, this recipe delivers an explosion of flavor that will have your family asking for seconds. The magic happens when the robust taco seasoning blends with the mild green chile enchilada sauce, creating a perfectly balanced profile that’s rich and savory without being overwhelmingly spicy. This ensures it’s a hit with all ages, even those with more sensitive palates.
The beauty of a casserole lies in its ability to bring together diverse ingredients into a harmonious dish, and this enchilada bake is a prime example. The bottom layer of fluffy Bisquick provides a unique, biscuit-like crust that perfectly complements the creamy, savory chicken and cheese filling. Every spoonful offers a delightful combination of textures and tastes, making each bite an experience to savor. It’s the kind of meal that feels special, yet requires so little hands-on time, making it ideal for the busiest of schedules.

Frequently Asked Questions (FAQs) About Bisquick Chicken Enchilada Bake
Here are some common questions to help you master this delicious and easy enchilada bake:
What is the best chicken to use for this casserole?
For ultimate convenience and to drastically cut down on prep time, we highly recommend using a store-bought rotisserie chicken. Simply dice it up, and you’re ready to go. If you have any leftover cooked chicken from a previous meal, that works wonderfully too! Alternatively, you can easily bake or boil a couple of chicken breasts and then dice them for this recipe. Even canned chicken (two 10-ounce cans, drained) can be a viable option in a pinch, though rotisserie chicken offers superior flavor and moisture.
What toppings would you suggest for this enchilada bake?
Get creative with your toppings! The sky’s the limit when it comes to personalizing your enchilada bake. Some fantastic options include a dollop of cool sour cream or plain Greek yogurt, thinly sliced black olives, crisp shredded lettuce, and fresh diced tomatoes. You can also add chopped fresh cilantro, sliced green onions, or even a spoonful of guacamole or salsa. Essentially, anything you would enjoy on a classic taco or enchilada will enhance this bake beautifully.
What could I use instead of Bisquick mix?
While Bisquick is fantastic for its ease and consistent results, you can certainly use any other brand of pre-made biscuit mix as a substitute. Most biscuit mixes will perform similarly. If you prefer a homemade touch, you can easily make your own Homemade Bisquick-style baking mix from scratch using flour, baking powder, salt, and shortening or butter. This allows for greater control over ingredients, including healthier alternatives.
Could I add beans or other vegetables to the casserole?
Absolutely! Adding beans is a fantastic way to boost fiber and protein. Pinto beans or black beans, thoroughly rinsed and drained, would be excellent additions. You could also incorporate corn (fresh, frozen, or canned), diced bell peppers (red, green, or yellow), or finely chopped onions into the chicken mixture before spreading it over the Bisquick layer. This adds extra nutrients, color, and texture to the dish.
What should I serve alongside the Chicken Enchilada Bake?
To complement the rich flavors of the casserole, a light and refreshing side dish is often best. My personal preference would be a simple green salad with a light vinaigrette or some steamed vegetables like broccoli florets or green beans. If you’re looking for more substantial sides and don’t mind extra carbohydrates, a flavorful restaurant-style Mexican rice or some homemade Slow Cooker Refried Beans would be absolutely delicious and complete the meal.
How do I store and reheat leftovers?
Storing leftovers correctly ensures you can enjoy this delicious bake for days. Place any remaining casserole in an airtight container and refrigerate for up to 3 days. For longer storage, this casserole freezes beautifully. Transfer it to a freezer-safe container or wrap individual portions tightly in plastic wrap and then foil. It will last for up to 3 months in the freezer. To reheat, thaw overnight in the refrigerator if frozen, then warm in the oven at 350°F (175°C) until heated through and bubbly, or in the microwave for individual servings.

Essential Ingredients for Your Delicious Bisquick Chicken Enchilada Bake
The beauty of this Bisquick Chicken Enchilada Bake lies in its simplicity and the readily available nature of its core ingredients. Each component plays a vital role in creating the ultimate comfort food experience.
INGREDIENTS NEEDED: (SEE RECIPE CARD BELOW FOR FULL MEASUREMENTS)
- Bisquick Mix: This versatile baking mix forms the crucial base of our casserole, providing a light, fluffy, and slightly savory crust that soaks up all the delicious flavors. You can use the standard store-bought mix for convenience, or for a more wholesome option, consider making your own homemade Bisquick mix. Any other brand of biscuit mix should also work well.
- Water: Essential for mixing with the Bisquick to create the batter for the base layer.
- Mild Green Chile Enchilada Sauce: This is the heart of the enchilada flavor. The mild green chile variety offers a vibrant, tangy, and slightly earthy taste without overpowering heat, making it family-friendly. If you prefer a bolder, richer flavor, feel free to swap it out for a red enchilada sauce.
- Cream of Chicken Soup: A classic casserole ingredient, canned cream of chicken soup provides a luscious, creamy texture and acts as a binding agent, ensuring the filling is moist and cohesive. For those who prefer to avoid canned soups, making your own homemade cream of chicken soup is a great alternative that offers fresher flavors and allows control over ingredients.
- Taco Seasoning: This spice blend is key to infusing the chicken mixture with authentic Tex-Mex flavors. It typically includes chili powder, cumin, paprika, onion powder, and garlic powder, delivering a warm and savory kick. You can easily use a pre-made packet for convenience, or personalize the flavor by using this homemade taco seasoning recipe.
- Diced Cooked Chicken: The star protein of our bake. Using a store-bought rotisserie chicken is the ultimate time-saver, making prep incredibly quick and easy. Its tender, seasoned meat is perfect for this casserole. Alternatively, you can use any leftover cooked chicken you have on hand, or quickly boil or bake a few chicken breasts and dice them. For emergency meals, two 10-ounce cans of drained, shredded chicken can also work.
- Shredded Monterey Jack Cheese: This cheese is chosen for its excellent melting properties and mild, creamy flavor, which perfectly complements the other ingredients. While pre-shredded varieties from a bag are convenient, shredding cheese fresh from a block often results in a smoother melt. For variations, feel free to use sharp cheddar cheese, creamy mozzarella, or spicy pepper jack cheese if you desire a bit more heat. Any easily meltable shredded cheese you enjoy will be a good fit.

Step-by-Step Guide: Crafting Your Bisquick Chicken Enchilada Bake
Creating this satisfying Bisquick Chicken Enchilada Bake is a straightforward process, designed for efficiency and delicious results. Follow these simple steps to bring this family-favorite casserole to life.
To begin, preheat your oven to a comforting 375°F (190°C). As your oven warms, prepare a 9×13-inch baking dish by generously spraying it with a nonstick cooking spray. This crucial step ensures that your delicious casserole will slide out easily without sticking.

In a medium-sized mixing bowl, combine the Bisquick mix with water. Stir these two ingredients together thoroughly until they form a consistent batter. Don’t worry if the batter appears slightly lumpy; this is perfectly normal for Bisquick. Once mixed, pour this batter evenly into the prepared baking dish, spreading it from edge to edge to create a uniform base. This will be the delicious, biscuit-like crust of your enchilada bake.
Now, for the flavorful filling! To minimize cleanup, you can use the same bowl you just used for the Bisquick batter. In this bowl, combine the can of mild green chile enchilada sauce, the can of cream of chicken soup, your diced cooked chicken, the taco seasoning, and one cup of shredded Monterey Jack cheese. Mix all these components together until they are well combined and the chicken is evenly coated in the rich, creamy sauce. This ensures every bite will be packed with flavor.

Carefully spoon the prepared chicken and sauce mixture over the Bisquick layer in the baking dish, spreading it out evenly to cover the entire base. This creates a beautiful, multi-layered casserole that’s as appealing to the eye as it is to the palate.

Finally, generously top the entire casserole with the remaining shredded cheese. This top layer will melt into a golden, bubbly crust, sealing in the moisture and adding an irresistible cheesy finish. Place the baking dish into your preheated oven and bake uncovered for approximately 30 minutes. You’ll know it’s ready when the cheese is beautifully melted, golden brown around the edges, and the casserole is bubbling invitingly.
Once baked to perfection, remove the Bisquick Chicken Enchilada Bake from the oven. Allow it to cool for several minutes before slicing and serving. This resting period helps the casserole set, making it easier to cut into neat portions. Garnish each serving with your favorite toppings, such as fresh shredded lettuce, juicy diced tomatoes, a dollop of sour cream, or a sprinkle of fresh cilantro, and prepare for rave reviews!

Serving Suggestions and Perfect Pairings for Your Enchilada Bake
The Bisquick Chicken Enchilada Bake is a complete meal in itself, but a few well-chosen accompaniments can elevate the dining experience. For toppings, offer a vibrant spread of sour cream or Greek yogurt, shredded iceberg lettuce for a crisp crunch, fresh diced tomatoes for acidity, and sliced black olives for a briny touch. Fresh cilantro or sliced green onions add a pop of color and herbaceousness.
When it comes to side dishes, a simple green salad with a light vinaigrette provides a refreshing contrast to the richness of the casserole. For a more traditional Mexican-inspired spread, consider serving it alongside fluffy Mexican rice or savory slow cooker refried beans. Corn on the cob or a fresh corn and black bean salsa would also be excellent choices. For beverages, a cool glass of iced tea, horchata, or even a light Mexican beer (for adults) would pair wonderfully with the flavors.
Why This Enchilada Casserole Deserves a Spot in Your Recipe Rotation
In a world where time is a precious commodity, finding recipes that deliver maximum flavor with minimal effort is a game-changer. The Bisquick Chicken Enchilada Bake is precisely that kind of recipe. It’s incredibly easy to prepare, relying on smart shortcuts like rotisserie chicken and a ready-made baking mix. This means less time in the kitchen and more time enjoying delicious food with your loved ones.
Beyond its convenience, this casserole is a true crowd-pleaser. Its mild yet vibrant flavors appeal to a wide range of palates, making it a perfect choice for family dinners, potlucks, or casual entertaining. It’s also remarkably versatile, allowing for easy customization with additional vegetables or different types of cheese to suit your preferences. Experience the joy of a homemade meal without the fuss, and make the Bisquick Chicken Enchilada Bake a beloved part of your culinary repertoire.
Craving More Comfort Food? Explore These Related Recipes!
- Cornbread Taco Bake
- White Chicken Enchiladas
- Bisquick Coffee Cake
- Bisquick Taco Casserole
- Bisquick Burrito Bake
- Chicken Chimichangas
- Biscuit Blueberry Cake with Bisquick
- Taco Bubble Up
- Mexican Lasagna
- Crock Pot Refried Beans
- Copycat Taco Bell Mexican Pizza
- White Chicken Enchiladas (For Two)
- Chicken Enchilada Casserole
- Tamale Pie
Originally posted: September 2014
Updated photos & republished: April 2024
Bisquick Chicken Enchilada Bake Recipe Card

Bisquick Chicken Enchilada Bake
Bisquick Chicken Enchilada Bake is a delicious casserole made with rotisserie chicken, taco seasoning, enchilada sauce and Monterey Jack cheese.
Based on 22 Reviews.
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Prep Time: 10 minutes | Cook Time: 30 minutes | Total Time: 40 minutes
Servings: 6 servings
Author: Brandie Skibinski
Ingredients
Main Ingredients:
- 2 cups Original Bisquick mix
- 1 cup water
- 10 ounce can mild green chile enchilada sauce
- 10.75 ounce can cream of chicken soup
- 2 Tablespoons taco seasoning
- 2 cups diced, cooked chicken
- 1 cup shredded Monterey Jack cheese
For Topping:
- 1 cup shredded Monterey Jack cheese
- Dried parsley (optional)
Instructions
- Preheat oven to 375°F degrees. Spray a 9×13-inch baking dish with nonstick cooking spray.
In a medium bowl, combine 2 cups Original Bisquick mix with 1 cup water. Stir well (batter will be lumpy).

Pour into baking dish and spread out evenly.

Using the same bowl, combine 10 ounce can mild green chile enchilada sauce, 10.75 ounce can cream of chicken soup, 2 Tablespoons taco seasoning, 2 cups diced, cooked chicken and 1 cup shredded Monterey Jack cheese.

Combine well then evenly spread over the Bisquick layer.

Top with remaining 1 cup shredded Monterey Jack cheese.

Bake uncovered for 30 minutes, until bubbly and golden around the edges. Top with a little dried parsley (optional) or chopped cilantro and serve!

Notes
- Please refer to my FAQ’s (Frequently Asked Questions) and ingredient list above for other substitutions or for the answers to the most common questions.
Course: Main Course
Cuisine: American
Nutrition
Calories: 399kcal | Carbohydrates: 30g | Protein: 20g | Fat: 21g | Sodium: 1639mg | Fiber: 1g | Sugar: 5g
Nutritional Disclaimer
“The Country Cook” is not a dietician or nutritionist, and any nutritional information shared is an estimate. If calorie count and other nutritional values are important to you, we recommend running the ingredients through whichever online nutritional calculator you prefer. Calories and other nutritional values can vary quite a bit depending on which brands were used.
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